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Cynomolgus TSLP (R127A, R130S) Protein
Catalog Number: orb613661
Product Overview
| Product Name | Cynomolgus TSLP (R127A, R130S) Protein |
|---|---|
| Catalog Number | orb613661 |
| Reactivity | Monkey |
| Conjugation | Unconjugated |
| Endotoxins | 1.0 EU per μg |
| Target | TSLP |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | Powder |
|---|---|
| Preservatives | PBS, pH7.4 |
| Storage | -20℃ |
| Tag | C-10×His |
| Note | For research use only. |
| Protein Sequence | XP_005557555.1 |
| Purity | 90% |
| MW | 16.9 kDa |
| Source | Cynomolgus TSLP (R127A, R130S) Protein, His Tag (orb613661) is expressed from human 293 cells (HEK293). It contains AA Tyr 29 - Gln 159 (Accession # A0A7N9CAT7-1 (R127A, R130S)). |
| Biological Origin | Cynomolgus |
| Expression Region | Tyr 29 - Gln 159 |
| NCBI | XP_005557555.1 |
Product Description
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
Application Notes
| Application Notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.9 kDa. The protein migrates as 21-30 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation. |
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