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美国Product Overview
Product Name | Human NKG2D / CD314 Protein |
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Catalog Number | orb653660 |
Reactivity | Human |
Conjugation | Unconjugated |
Endotoxins | 0.1 EU per μg |
Target | NKG2D |
Alternative Names | (click to expand) |
Product Properties
Form/Appearance | Powder |
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Preservatives | Tris with Glycine, Arginine and NaCl, pH7.5 |
Storage | -20℃ |
Tag | N-mFc(mIgG2a) |
Note | For research use only. |
Protein Sequence | NP_031386.2 (T72A) |
Purity | 95% |
MW | 43.5 kDa |
Source | Human NKG2D, Mouse IgG2a Fc Tag (orb653660) is expressed from human 293 cells (HEK293). It contains AA Ile 73 - Val 216 (Accession # P26718-1). |
Biological Origin | Human |
Expression Region | Ile 73 - Val 216 |
NCBI | T72, NP_031386.2 |
Product Description
NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.
Application Notes
Application Notes | This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 43.5 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
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