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Product Overview
| Product Name | IRG1 antibody |
|---|---|
| Catalog Number | orb184387-CF488A |
| Species/Host | Rabbit |
| Reactivity | Human |
| Conjugation | CF488A |
| Tested applications | ELISA, ICC, IF, IHC-P |
| Immunogen | KLH conjugated synthetic peptide derived from the region aa11-90 of human IRG1 |
| Target | IRG1. Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells. |
| Alternative Names | (click to expand) |
Product Properties
| Form/Appearance | Liquid: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
|---|---|
| Concentration | - 100 μg (in 520 μl): 0.19 mg/ml |
| Storage | Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles. |
| Note | For research use only. |
| Isotype | IgG |
| Clonality | Polyclonal |
| Purity | Affinity purified by Protein A |
| MW | 53 kDa |
| Uniprot ID | A6NK06 (Human) |
| Entrez | 730249 |
Product Description
Rabbit polyclonal antibody to IRG1, which is also known as CAD. It is frequently found in the mitochondrion and is expressed in the microglia and macrophage cells. It is overexpressed in the LPS-tolerized macrophages. This protein can extensively act as a negative regulator of the toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages and is involved in the inhibition of the inflammatory response.
Application Notes
| Dilution Range | ICC: 1:100-500, IF: 1:100-500 |
|---|
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