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美国Product Name | Mouse NOTCH1 Protein |
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Catalog Number | orb653659 |
Reactivity | Mouse |
Conjugation | Unconjugated |
Endotoxins | 1.0 EU per μg |
Target | NOTCH1 |
Alternative Names | (click to expand) |
Form/Appearance | Powder |
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Preservatives | PBS, pH7.4 |
Storage | -20℃ |
Tag | C-10×His |
Note | For research use only. |
Protein Sequence | NP_032740.3 |
Purity | 95% |
MW | 55.4 kDa |
Source | Mouse NOTCH1, His Tag (orb653659) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - Gln 526 (Accession # Q01705-1). |
Biological Origin | Mouse |
Expression Region | Ala 19 - Gln 526 |
NCBI | NP_032740.3 |
NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
Application Notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.4 kDa. The protein migrates as 58-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
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