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美国Product Overview
Product Name | Mouse Siglec-10 Protein |
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Catalog Number | orb651995 |
Reactivity | Mouse |
Conjugation | Unconjugated |
Endotoxins | 1.0 EU per μg |
Target | Siglec-10 |
Alternative Names | (click to expand) |
Product Properties
Form/Appearance | Powder |
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Preservatives | 25 mM MES, 150 mM NaCl, pH5.5 |
Storage | -20℃ |
Tag | C-10×His |
Note | For research use only. |
Protein Sequence | NP_766488.2 |
Purity | 90% |
MW | 60.7 kDa |
Source | Mouse Siglec-10, His Tag (orb651995) is expressed from human 293 cells (HEK293). It contains AA Met 18 - Lys 543 (Accession # Q80ZE3-1). |
Biological Origin | Mouse |
Expression Region | Met 18 - Lys 543 |
NCBI | NP_766488.2 |
Product Description
The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
Application Notes
Application Notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.7 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
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