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Product Overview
| Product Name | XL177A |
|---|---|
| Catalog Number | orb1089362 |
Product Properties
| Note | For research use only. |
|---|---|
| Formula | C6H14N2O |
| MW | 130.1882 |
| CAS Number | [188719-92-8] |
| SMILES | O([H])/N=C(/C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])\N([H])[H] |
Product Description
XL177A is a potent USP7 inhibitor. XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome. Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells.
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